Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF. Issue 3 (8th March 2016)

• Record Type: Journal Article
• Authors: Pokorney, Sean D.; Piccini, Jonathan P.; Stevens, Susanna R.; Patel, Manesh R.; Pieper, Karen S.; Halperin, Jonathan L.; Breithardt, Günter; Singer, Daniel E.; Hankey, Graeme J.; Hacke, Werner; Becker, Richard C.; Berkowitz, Scott D.; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M.
• Other Names: Anderson J. investigator.; Bedwell N. investigator.; Bilsker M. investigator.; Bruce G. investigator.; Agah R. investigator.; DeSantis M. investigator.; Eisenberg S. investigator.; Flores A. investigator.; Herzog W. investigator.; Klein S. investigator.; Snyder H. investigator.; Krueger S. investigator.; Almaguer E. investigator.; Lavie E. investigator.; Lee C. investigator.; Mallis G. investigator.; Modi M. investigator.; Woodworth G. investigator.; Niazi I. investigator.; Peart B. investigator.; Sundaram S. investigator.; Snoddy B. investigator.; Sotolongo R. investigator.; Moloney J. investigator.; Vijayaraghavan K. investigator.; Whittier F. investigator.; Yellen L. investigator.; Banerjee S. investigator.; Lustgarten D. investigator.; Suresh D. investigator.; Gelernt M. investigator.; Levinson L. investigator.; Ghanekar R. investigator.; Kneller G. investigator.; Hall C. investigator.; Fadl Y. investigator.; Pirwitz M. investigator.; French W. investigator.; Mayer N. investigator.; Pugeda J. investigator.; Steel K. investigator.; Mody F. investigator.; Malik A. investigator.; Chandna H. investigator.; Go A. investigator.; Emlein G. investigator.; Bowden W. investigator.; Moscoso R. investigator.; Hodson R. investigator.; Berk M. investigator.; Pan D. investigator.; Pappas J. investigator.; Orchard R. investigator.; Lynchard G. investigator.; Vijay N. investigator.; Khan W. investigator.; El Khadra M investigator.; Antonishen M. investigator.; Cucher F. investigator.; Staab M. investigator.; Zebrack J. investigator.; Borromeo S investigator.; Heilman J. investigator.; Chaturvedi S. investigator.; Makam S. investigator.; Turk S. investigator.; Hyers T. investigator.; Williams G. investigator.; Labroo A. investigator.; Gill S. investigator.; Myears D. investigator.; Weinstein J. investigator.; Shanes J. investigator.; Chandrashekhar Y. investigator.; Shah S. investigator.; Reiter W. investigator.; Logemann T. investigator.; Almquist A. investigator.; Bhagwat R. investigator.; Tak T. investigator.; Shen‐Ling J. investigator.; Patel P. investigator.; Artis A. investigator.; Arouni A. investigator.; Lauer M. investigator.; Kinney K. investigator.; Elsen J. investigator.; Roan P. investigator.; Villafria R. investigator.; Sumpter M. investigator.; Ip J. investigator.; Welka S. investigator.; Schifferdecker B. investigator.; Sandoval R. investigator.; Speirs S. investigator.; Jones A. investigator.; Haldis T. investigator.; Kazmierski J. investigator.; Sutherland J. investigator.; Dietrich D. investigator.; Telfer E. investigator.; Berry J. investigator.; McElveen A. investigator.; Russell J. investigator.; Sackett M. investigator.; Antonios N. investigator.; Smith D. investigator.; Vora K. investigator.; Kirby A. investigator.; Lui H. investigator.; Mego D. investigator.; Ziada K. investigator.; Navas J. investigator.; Taussig A. investigator.; Koren M. investigator.; Vogel C. investigator.; Saba F. investigator.; Parrott C. investigator.; Schneider R. investigator.; Shirwany A. investigator.; Rubin M. investigator.; Treasure C investigator.; Bertolet B. investigator.; Chang M. investigator.; Langberg J. investigator.; Becker R. investigator.; Cohen Y. investigator.; McGrew F. investigator.; White J. investigator.; Arzola F. investigator.; Zelenka J. investigator.; Tannenbaum A. investigator.; Fernandes V. investigator.; Jamnadas P. investigator.; Agamasu J. investigator.; Collins B. investigator.; Jauch W. investigator.; Sasseen B. investigator.; Hotchkiss D. investigator.; Abadier R. investigator.; Osunkoya A. investigator.; Schlau A. investigator.; Chappel C. investigator.; Foster M. investigator.; Braun E. investigator.; Mostel E. investigator.; Capo J. investigator.; Ashchi M. investigator.; Howard V. investigator.; Albirini A. investigator.; Burger A. investigator.; Rolston D. investigator.; Staniloae C. investigator.; Bacon J. investigator.; Wiseman A. investigator.; McGarvey J investigator.; Sonel A. investigator.; Hamroff G. investigator.; Chang D. investigator.; Daboul N. investigator.; Broderick G. investigator.; Meholick A. investigator.; Corbelli J. investigator.; Silverman R. investigator.; Raffetto J. investigator.; Fishberg R. investigator.; Georgeson S. investigator.; Held J. investigator.; Seidner M. investigator.; Saint‐Jacques H. investigator.; Heitner J. investigator.; Kutalek S. investigator.; Friedlander I. investigator.; Hutchinson B. investigator.; Walia J. investigator.; Kondo N. investigator.; Smiley N. investigator.; Blitz L. investigator.; Dale H. investigator.; Sulman S. investigator.; Szulawski I. investigator.; Modares F. investigator.; Martin R. investigator.; Nahhas A. investigator.; Renzi M. investigator.; Akyea‐Djamson A. investigator.; Alfieri A. investigator.; Sandhu J. investigator.; Voyce S. investigator.; Amaram S. investigator.; Meyerrose G. investigator.; Shoukfeh M. investigator.; Lee F. investigator.; Villegas B. investigator.; Idowu O. investigator.; Khera A. investigator.; Sam C. investigator.; Vo A. investigator.; Lieber I. investigator.; Smith T. investigator.; Awan N. investigator.; Tsai C. investigator.; Ganim R. investigator.; Alzaghrini G. investigator.; Pitt W. investigator.; Shepherd A. investigator.; Tang S. investigator.; Stoltz S. investigator.; Nelson W. investigator.; Cox S. investigator.; Meymandi S. investigator.; Melucci M. investigator.; Thomas G. investigator.; Gogia H. investigator.; Machell C. investigator.; Chandrasekaran S. investigator.; Brown C. investigator.; Jetty P. investigator.; Miller G. investigator.; Dykstra G. investigator.; Jaffrani N. investigator.; Zakhary B. investigator.; Caruso A. investigator.; Zolty R. investigator.; Fox D. investigator.; Jacobs G. investigator.; Lebenthal M. investigator.; Mukherjee S. investigator.; Zimetbaum P. investigator.; Kingsley J. investigator.; Jones R. investigator.; Robinson V. investigator.; Kenton D. investigator.; Usedom J. investigator.; Williams S. investigator.; Snipes C. investigator.; Wilson V. investigator.; Hasty R. investigator.; Shoemaker J. investigator.; Donahue M. investigator.; Al‐Saghir Y. investigator.; Thomsen E. investigator.; Yarows S. investigator.; Chastain S. investigator.; McLaughlin P. investigator.; Wakham M. investigator.; Shrestha D. investigator.; Simmons J. investigator.; Fisher D. investigator.; Seymour Z. investigator.; Frandsen B. investigator.; First B. investigator.; Sharpe C. investigator.; Popeil L. investigator.; Guthrie R. investigator.; Hunter J. investigator.; Alvarado O. investigator.; Sandberg J. investigator.; Gutman N. investigator.; Belber A. investigator.; Arkhipov M. investigator.; Ballyzek M. investigator.; Baranov A. investigator.; Barbarash O. investigator.; Barbarich V. investigator.; Belenky D. investigator.; Berkovich O. investigator.; Bokarev I. investigator.; Boyarkin M. investigator.; Vaniev S. investigator.; Volkova E. investigator.; Gratsiansky N. investigator.; Demin A. investigator.; Zadionchenko V. investigator.; Zateyshchikov D. investigator.; Zrazhevsky K. investigator.; Mazaev V. investigator.; Martynov A. investigator.; Mikhailov S. investigator.; Mkrtchian V. investigator.; Novozhenov V. investigator.; Raskina T. investigator.; Rebrov A. investigator.; Sanina N. investigator.; Simanekov V. investigator.; Sitnikova M. investigator.; Smolenskaya O. investigator.; Stryuk R. investigator.; Storozhakov G. investigator.; Tankhilevich B. investigator.; Tereschenko S. investigator.; Khokhlov A. investigator.; Khrustalev O. investigator.; Chernov S. investigator.; Shvarts Y. investigator.; Shubik Y. investigator.; Shulman V. investigator.; Yakushin S. investigator.; Bugrova O. investigator.; Ivleva A. investigator.; Libis R. investigator.; Khozyainova N. investigator.; Maslov S. investigator.; Baranova E. investigator.; Sherenkov A. investigator.; Libov I. investigator.; Lusov V. investigator.; Chumakova G. investigator.; Kuznetsov V. investigator.; Ryamzina I. investigator.; Reshetko O. investigator.; Boldueva S. investigator.; Alekseeva N. investigator.; Novikova T. investigator.; Dvornikov V. investigator.; Idrisova E. investigator.; Shostak N. investigator.; Yarokhno N. investigator.; Tebloev K. investigator.; Treshkur T. investigator.; Mazurov V. investigator.; Loktin E. investigator.; Sedavnyh I. investigator.; Alexeeva O. investigator.; Yakhontova P. investigator.; Repin A. investigator.; Izmozherova N. investigator.; Kostenko V. investigator.; Fokin A. investigator.; Ketova G. investigator.; Kouz S. investigator.; Leader R. investigator.; Ayala‐Paredes F. investigator.; Luton R. investigator.; Ma P. investigator.; Pandey S. investigator.; Pesant Y. investigator.; Senior R. investigator.; Vertes G. investigator.; Bell A. investigator.; Crowley D. investigator.; Vizel S. investigator.; Lasko B. investigator.; Landry D. investigator.; Berger L. investigator.; Heath J. investigator.; Bessoudo R. investigator.; Ling M. investigator.; Tellier G. investigator.; Berlingieri J. investigator.; Kafka H. investigator.; Hill L. investigator.; Mazza G. investigator.; O'Mahony W. investigator.; Chilvers M. investigator.; O'Mahony M. investigator.; Newman D. investigator.; Silagy S. investigator.; Heffernan M. investigator.; Bennett M. investigator.; Bhesania T. investigator.; Rockman G. investigator.; Ng K. investigator.; Kalra B. investigator.; Meneses G. investigator.; Liang W. investigator.; Cheung M. investigator.; Kozak J. investigator.; Pugen G. investigator.; Vavougios J. investigator.; Kates M. investigator.; Nunes‐Vaz C. investigator.; Jaffer S. investigator.; Orfi J. investigator.; Faiers A. investigator.; Chung C. investigator.; Felsen S. investigator.; Bergman S. investigator.; Bernstein I. investigator.; Brownscombe L. investigator.; Stockdill J. investigator.; Silver E. investigator.; Ezekiel D. investigator.; Jagan N. investigator.; Khurana M. investigator.; Reisler H. investigator.; Goldman H. investigator.; Maung T. investigator.; Wong F. investigator.; Gillis G. investigator.; Vexler R. investigator.; 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Archibald J. investigator.; Abram N. investigator.; Teitelbaum E. investigator.; Ebrahim I. investigator.; Siebert R. investigator.; van Zyl L. investigator.; Theron H. investigator.; Lloyd E. investigator.; Sommers R. investigator.; Podgorski G. investigator.; Steingo L. investigator.; Dalby A. investigator.; Bayat J. investigator.; Herbst L. investigator.; Bester F. investigator.; Corbett C. investigator.; Bennett J. investigator.; Roodt A. investigator.; Roux J. investigator.; Abelson M. investigator.; Mohamed Z. investigator.; Nortje H. investigator.; Da Silva A. investigator.; Nikolaides K. investigator.; Liagkas K. investigator.; Papasteriadis E. investigator.; Achimastos A. investigator.; Koliopoulos N. investigator.; Trikas A. investigator.; Manolis A. investigator.; Ruiter J. investigator.; Basart D. investigator.; Crijns H. investigator.; Withagen A. investigator.; Janssen M. investigator.; Van Langeveld R investigator.; van Gelder I. investigator.; Hamer B. investigator.; Van Der Heijden R investigator.; Hertzeberger D. investigator.; Van Hessen M investigator.; Pieterse M. investigator.; Groutars R. investigator.; Kuijper A. investigator.; De Ruiter G investigator.; van Boven A. investigator.; Hoogslag P. investigator.; Kragten H. investigator.; Thijssen H. investigator.; Veldkamp R. investigator.; Scavee C. investigator.; Heidbuchel H. investigator.; Debruyne P. investigator.; Deruyter B. investigator.; El Ali H investigator.; Goethals M. investigator.; Cytryn R. investigator.; Striekwold H. investigator.; De Wolf L investigator.; Goethals P. investigator.; Provenier F. investigator.; Hellemans S. investigator.; Galinier M. investigator.; Coisne D. investigator.; Koenig A. investigator.; Galley D. investigator.; Destrac S. investigator.; Leduc J. investigator.; Rifai A. investigator.; Citron B. investigator.; Ellie E. investigator.; Fournier P. investigator.; Steg G. investigator.; Landel R. investigator.; Robinson A. investigator.; Ziegler F. investigator.; Boulliat J. investigator.; Zuber M. investigator.; Vida M. investigator.; Galve Basilio E. investigator.; Lopez M. investigator.; Íñiguez C. investigator.; Iglesias Alonso L. investigator.; Cavero Gibanel M. investigator.; Olivan Martinez J. investigator.; Calvo Iglesias F. investigator.; Marco Vera P. investigator.; Bruguera Cortada J. investigator.; Jaber Houbani A. investigator.; Merino J. investigator.; Olaz Preciado F. investigator.; Balaguer J. investigator.; de la Hera Galarza J investigator.; Martinez Rubio A. investigator.; Fontcuberta J. investigator.; Sotillo Marti J. investigator.; Gonzalez Juanatey J. investigator.; Del Campo R. investigator.; Vivanco G. investigator.; Alvarez Garcia P. investigator.; Pelayo M. investigator.; Lippai J. investigator.; Zamolyi K. investigator.; Károly T. investigator.; Vertes A. investigator.; Nagy A. investigator.; Kosa I. investigator.; Janosi A. investigator.; Lupkovics G. investigator.; Kalo E. investigator.; Forster T. investigator.; Kis E. investigator.; Tenczer J. investigator.; 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Mendoza A. investigator.; Negron S. investigator.; Watanabe L. investigator.; Medina F. investigator.; Virgen Carrilo L. investigator.; Alvarez Lopez H. investigator.; Rodriguez I. investigator.; Leiva‐Pons J. investigator.; Baños Velasco A. investigator.; Villarreal‐Careaga J. investigator.; De los Rios M investigator.; Gamba M. investigator.; Llamas Esperon G. investigator.; Villeda E. investigator.; Ahuad Guerrero A. investigator.; Alvariqueta A. investigator.; Amuchastegui M. investigator.; Bluguermann J. investigator.; Caime G. investigator.; Cuneo C. investigator.; Gabito A. investigator.; Garcia Brasca D. investigator.; Hominal M. investigator.; Jure H. investigator.; Luquez H. investigator.; Montana O. investigator.; Piskorz D. investigator.; Listorti S. investigator.; Serra J. investigator.; Sessa H. investigator.; Varini S. investigator.; Vita N. investigator.; Aiub J. investigator.; MacKinnon I. investigator.; Chekherdemian S. investigator.; Castagnino J. investigator.; Cimbaro Canella J. investigator.; 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Quintero A. investigator.; Pava L. investigator.; Botero Lopez R. investigator.; Luengas C. investigator.; Hernandez E. investigator.; Sanchez D. investigator.; Poveda C. investigator.; Coronel J. investigator.; Beltran R. investigator.; Jaramillo C. investigator.; Pardo J. investigator.; Ponte Negretti C. investigator.; Isea J. investigator.; Vergara G. investigator.; Morr I. investigator.; Sim K. investigator.; Wan Ahmad W. investigator.; Yusof Z. investigator.; Rosman A. investigator.; Basri H investigator.; Thompson P. investigator.; Jeffery I. investigator.; Purnell P. investigator.; Roberts‐Thomson P. investigator.; Heddle W. investigator.; Waites J. investigator.; Walters D. investigator.; Amerena J. investigator.; Challa P. investigator.; Karrasch J. investigator.; Lowy A. investigator.; Fitzpatrick D. investigator.; Parsons M. investigator.; Phan T. investigator.; Bladin C. investigator.; Donnan G. investigator.; Aroney G. investigator.; Gerraty R. investigator.; Anderson C. investigator.; Blombery P. investigator.; Martin P. investigator.; Tissa Wijeratne K. investigator.; Cross D. investigator.; Crimmins D. investigator.; Packham D. investigator.; Jackson D. investigator.; Chua W. investigator.; Merino R. investigator.; Magno M. investigator.; Tirador L. investigator.; Batalla E. investigator.; Manalo C. investigator.; Uy N. investigator.; Ebo G. investigator.; Reyes E. investigator.; Bernan A. investigator.; Richards M. investigator.; Hart H. investigator.; Mann S. investigator.; Fisher R. investigator.; Stewart R. investigator.; Wilkins G. investigator.; Barber A. investigator.; Tan R. investigator.; Ong H. investigator.; Singh R. investigator.; Sukonthasarn A. investigator.; Tanomsup S. investigator.; Krittayaphong R. investigator.; Piamsomboon C. investigator.; Piyayotai D. investigator.; Sunsaneewitayakul B. investigator.; Baek S. investigator.; Seo H. investigator.; Rim S. investigator.; Kim C. investigator.; Kim K. investigator.; Ryu K. investigator.; Jo S. investigator.; Tahk S. investigator.; Lee H. investigator.; Kim Y. investigator.; Shin D. investigator.; Choi Y. investigator.; Chung N. investigator.; Namgung J. investigator.; Hong T. investigator.; Shin W. investigator.; Jin S. investigator.; Yan X. investigator.; Fu G. investigator.; Lu G. investigator.; Yang K. investigator.; Xu D. investigator.; Chen J. investigator.; Liu J. investigator.; Wu S. investigator.; Song J. investigator.; Liao Y. investigator.; Xu B. investigator.; Li Z. investigator.; Ma S. investigator.; Yin Y. investigator.; Zhao Y. investigator.; Hu D. investigator.; Ma C. investigator.; Ma J. investigator.; Sun J. investigator.; Li H. investigator.; Hong X. investigator.; Yu B. investigator.; Lu Q. investigator.; Yang J. investigator.; Wu Z. investigator.; Li Y. investigator.; Huang Y. investigator.; Wang Y. investigator.; Liu M. investigator.; Cheng Y. investigator.; Yang T. investigator.; Chen K. investigator.; Wang H. investigator.; Yuan Z. investigator.; Wang J. investigator.; Zeng Z. investigator.; Chen Y. investigator.; Yavuzgil O. investigator.; Kozan O. investigator.; Etemoglu M. investigator.; Diker E. investigator.; Belgi A. investigator.; Ceyhan C. investigator.; Cin V. investigator.; Yilmaz O. investigator.; Ata N. investigator.; Altunkeser B. investigator.; Agacdiken Agir A. investigator.; Karadede A. investigator.; Topsakal R. investigator.; Gulati R. investigator.; Madhavan A. investigator.; Jain S. investigator.; Oomman A. investigator.; Janorkar S. investigator.; Kumar P. investigator.; Madhukar Naik A. investigator.; Thacker H. investigator.; Rajasekhar V. investigator.; Reddy R. investigator.; Keshavamurthy C. investigator.; Jain P. investigator.; Gowdappa B. investigator.; Gadkari M. investigator.; Abhyankar A. investigator.; Ramesh Babu B. investigator.; Vydianathan P. investigator.; Sinha S. investigator.; Garg N. investigator.; Rao S. investigator.; Gautam P. investigator.; Chockalingam K. investigator.; Kumbla M. investigator.; Panwar R. investigator.; Banker D. investigator.; Kaste M. investigator.; Jäkälä P. investigator.; Roine R. investigator.; Mihov A. investigator.; Raev D. investigator.; Yordanova V. investigator.; Dimitrova S. investigator.; Benov H. investigator.; Tsanova V. investigator.; Kyolean M. investigator.; Marchev S. investigator.; Stoikov A. investigator.; Zdravkov N. investigator.; Ramshev K. investigator.; Krastev A. investigator.; Stamenova P. investigator.; Angelova I. investigator.; Pencheva G. investigator.; Grigorova V. investigator.; Petrauskiene B. investigator.; Skripkauskiene I. investigator.; Raugaliene R. investigator.; Norkiene S. investigator.; Mazutavicius R. investigator.; Kavoliuniene A. investigator.; Aidietiene S. investigator.; Aganauskiene J. investigator.; Dailydkiene A. investigator.; Marcinkeviciene J. investigator.; Grigoniene L. investigator.; Anusauskiene J. investigator.; Kavaliauskiene R. investigator.; Lizogub V. investigator.; Rudenko L. investigator.; Tseluyko V. investigator.; Voronkov L. investigator.; Sychov O. investigator.; Svyshchenko Y. investigator.; Sirenko Y. investigator.; Serkova V. investigator.; Seredyuk N. investigator.; Pertseva T. investigator.; Netyazhenko V. investigator.; Lishnevska V. investigator.; Kupchynska O. investigator.; Koval O. investigator.; Koshukova G. investigator.; Karpenko O. investigator.; Grishyna O. investigator.; Faynyk A. investigator.; Dzyak G. investigator.; Dyadyk O. investigator.; Yena L. investigator.; Volkov V. investigator.; Rudyk I. investigator.; Kopytsya M. investigator.; Kononenko L. investigator.; Amosova K. investigator.; Zhurba S. investigator.; Kazimirko V. investigator.; Iuzkiv I. investigator.; Shershnyova O. investigator.; Khomazyuk T. investigator.; Batushkin V. investigator.; Vykhovanyuk I. investigator.; Popik G. investigator.; Skrebkov V. investigator.; Skurtov A. investigator.; Mishchenko T. investigator.; Lytvynenko N. investigator.; Sokolova L. investigator.; Vatutin M. investigator.; Shved M. investigator.; Rebrov B. investigator.; Kadina L. investigator.; Vajda M. investigator.; Ursol G. investigator.; Zheleznyy V. investigator.; Vysochanska T. investigator.; Gozhenko A. investigator.; Fan K. investigator.; Ho D. investigator.; Tse H. investigator.; Yu C. investigator.; Wong L. investigator.; Yeh H. investigator.; Pai P. investigator.; Hsieh I. investigator.; Huang C. investigator.; Hsieh Y. investigator.; Yin W. investigator.; Tsai L. investigator.; Huang T. investigator.; Chen C. investigator.; Chiang F. investigator.; Ueng K. investigator.; Charng M. investigator.; Marmor A. investigator.; Katz A. investigator.; Butnaru A. investigator.; Lewis B. investigator.; Eldar M. investigator.; Rosenhack S. investigator.; Elias N. investigator.; Koifman B. investigator.; Shochat M. investigator.; Swissa M. investigator.; Zimlichman R. investigator.; Bental T. investigator.; Weiss A. investigator.; Ganam R. investigator.; Elias M. investigator.; Nseir W. investigator.; Oliven A. investigator.; Brenner B. investigator.; Dayan M. investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 3(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-03-08
• Subjects: atrial fibrillation -- mortality -- rivaroxaban -- stroke -- warfarin; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.002197
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all‐cause mortality may guide interventions. Methods and Results: In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose‐adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all‐cause mortality in the 14 171 participants in the intention‐to‐treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow‐up, 1214 (8.6%) patients died. Kaplan–Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all‐cause mortality was observed between the rivaroxaban and warfarin arms ( P =0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33–1.70, P <0.0001) and age ≥75 years (hazard ratio 1.69, 95% CI 1.51–1.90, P <0.0001) were associated with higher all‐cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C‐index 0.677). Conclusions: In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration: URL:https://www.clinicaltrials.gov/ . Unique identifier: NCT00403767.