Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis. Issue 1 (20th April 2018)

• Record Type: Journal Article
• Authors: Lee, Dong Won; Kim, Dae Yeon; Hong, Ji Hyuck; Seo, Soo Hong; Kye, Young Chul; Ahn, Hyo Hyun
• Other Names: Rhyu Im Joo specialEditor.; Rhyu Im Joo guestEditor.; Lee Zonghoon guestEditor.; Yang Cheol‐Woong guestEditor.
• Is Part Of: Microscopy research and technique. Volume 82:Issue 1(2019)
• Page Start: 12
• Page End: 17
• Publication Date: 2018-04-20
• Subjects: actinic keratosis -- dermoscopy -- histopathology; Electron microscopy -- Technique -- Periodicals; Microscopy -- Periodicals; Microscopy -- Technique -- Periodicals; 502.825
• DOI: 10.1002/jemt.23043
• Languages: English
• ISSNs: 1059-910X

Abstract

Abstract: Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white‐to‐yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated. Furthermore, viable epidermal thickness, vessel lumen dimensions, existence and thickness of ortho‐ and parakeratosis, degree of sola elastosis, flag sign existence, and Roewert‐Huber classification were measured as histologic findings. Red background did not show a significant correlation with vascular dimension or viable epidermal thickness. When targetoid sign was present, vascular dimension was significantly larger but showed no correlation with viable epidermal thickness, parakeratosis or orthokeratosis. Solar elastosis level was significantly higher when white‐to‐yellow scale was present. According to Spearman's correlation analysis, ortho/parakeratotic thickness showed correlations with each other. The negative correlation between viable epidermal thickness and vascular dimension was also shown. Roewert‐Huber histologic AK classification showed no correlation with any factors we checked. Factors considered to be characteristic features of AK in dermoscopy seemed unassociated with histologic AK classification and additional research is needed to determine degree of dysplasia of AK lesions using dermoscopy. Abstract : Characteristic dermoscopic features of AK were not associated with histologic AK classification. The degree of photoaging was not significantly associated with dysplasia of the epidermis.