Conformational stabilization of isatin Schiff bases – biologically active chemical probes. Issue 17 (6th February 2017)

• Record Type: Journal Article
• Authors: Smirnov, Andrey S.; Nikolaev, Dmitriy N.; Gurzhiy, Vlad V.; Smirnov, Sergey N.; Suslonov, Vitaliy S.; Garabadzhiu, Alexander V.; Davidovich, Pavel B.
• Is Part Of: RSC advances. Volume 7:Issue 17(2017)
• Page Start: 10070
• Page End: 10073
• Publication Date: 2017-02-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra26779c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Two ways of conformation stabilization for isatin Schiff bases (group of biologically active compounds) are reported here: complexation with metals that stabilize E -conformer and substitution in the 4 th position of isatin core stabilizing Z -form. Abstract : Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational E ⇆ Z interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E -conformer and substitution in the 4 th position of the isatin core stabilizing the Z -form.