Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis. (March 2018)

• Record Type: Journal Article
• Authors: Romeo, Agostino; Moya, Ana; Leung, Tammy S.; Gabriel, Gemma; Villa, Rosa; Sánchez, Samuel
• Is Part Of: Applied materials today. Volume 10(2018)
• Page Start: 133
• Page End: 141
• Publication Date: 2018-03
• Subjects: Inkjet printing -- Non-enzymatic sensor -- Glucose -- Copper oxide -- Tear analysis; Materials science -- Periodicals; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1016/j.apmt.2017.12.016
• Languages: English
• ISSNs: 2352-9407

Abstract

Graphical abstract: Highlights: An all-printed electrochemical sensor for non-invasive and enzyme-free analysis of glucose. Multi-material electrodes fabricated by inkjet printing on flexible substrates. Combined beneficial factors: versatile fabrication, full electrode integration, enzyme-free detection. Requirements for analysis of tear glucose matched by our non-enzymatic glucose sensor. Abstract: Here, we present a flexible and low-cost inkjet printed electrochemical sensor for enzyme-free glucose analysis. Versatility, short fabrication time and low cost make inkjet printing a valuable alternative to traditional sensor manufacturing techniques. We fabricated electro-chemical glucose sensors by inkjet printing electrodes on a flexible polyethylene terephthalate substrate. CuO microparticles were used to modify our electrodes, leading to a sensitive, stable and cost-effective platform for non-enzymatic detection of glucose. Selectivity, reproducibility, and life-time provided by the CuO functionalization demonstrated that these sensors are reliable tools for personalized diagnostics and self-assessment of an individual's health. The detection of glucose at concentrations matching that of tear fluid allows us to envisage applications in ocular diagnostics, where painless and non-invasive monitoring of diabetes can be achieved by analyzing glucose contained in tears.