Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura. (2018)

• Record Type: Journal Article
• Authors: Nakayama, Shoko; Matsuda, Mitsuhiro; Adachi, Tatsuya; Sueda, Sanae; Ueda, Kayo; Kawahara, Kunimitsu; Ohashi, Yuka; Awaji, Sumie; Hashimoto, Shigeo; Matsumura, Itaru
• Is Part Of: Leukemia research reports. Volume 10(2018)
• Page Start: 1
• Page End: 3
• Publication Date: 2018
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2018.06.001
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: A 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the first case report of TNF- and IL-6-producing aggressive HGBL, NOS in the pleura, in which radiological findings mimicked pleural mesothelioma. The aggressive tumor progression in the present case may have been caused by abnormal cytokine production from lymphoma cells.