Controlled‐Release LCST‐Type Nonwoven Depots via Squeezing‐Out Thermal Response. Issue 3 (17th December 2018)

• Record Type: Journal Article
• Authors: Käfer, Florian; Vilensky, Rita; Vasilyev, Gleb; Zussman, Eyal; Agarwal, Seema
• Is Part Of: Macromolecular materials and engineering. Volume 304:Issue 3(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-17
• Subjects: drug delivery -- electrospinning -- fiber matrix -- lower critical solution temperature -- nanoparticles; Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/mame.201800606
• Languages: English
• ISSNs: 1438-7492

Abstract

Abstract: A novel thermoresponsive fibrous matrix as controlled release depots upon heating is described. The matrix is composed of electrospun fibers of a lower critical solution temperature (LCST)‐type poly(methacrylamide‐ co ‐ N‐tert ‐butylacrylamide‐ co ‐4‐acryloylbenzophenone) P(MAAm‐NtbAAm‐ABP) copolymer. Spherical particles, simulating depots of drugs, are embedded with liquid‐filled inter‐fiber spaces (pores). On heating above 25 °C up to 45 °C, the nanofibers undergo a contraction of about 40%. This solid deformation is attributed to the LCST transition. Fibrous matrix contraction drives expulsion of depots and water solution stored in the pores of the matrix, as evidenced by in situ observations. The liquid flow in the deformable porous medium demonstrates liquid drainage from the matrix as a function of temperature. Experimental results reveal that 70% of the particles are expelled from the matrix upon heating to 45 °C from room temperature. The presented particles encapsulation and release model system using LCST‐type fibrous matrix can be used as a transdermal patch. Abstract : A new release concept by use of large pore volume and porosity of 2D fibrous thermoresponsive membranes by temperature triggered squeezing‐out effect is shown. Fluorescently labeled with carboxylated latex nanoparticles loaded lower critical solution temperature‐type poly(methylacrylamide‐ co ‐ N‐tert ‐butylacrylamide‐ co ‐4‐acryloylbenzophenone) is used for detailed studies and in situ release while heating is monitored using real‐time fluorescence microscopy.