Preparation and biocompatibility evaluation of polypropylene mesh coated with electrospinning membrane for pelvic defects repair. (May 2018)

• Record Type: Journal Article
• Authors: Lu, Yao; Fu, Shaoju; Zhou, Shuanglin; Chen, Ge; Zhu, Chaoting; Li, Nannan; Ma, Ying
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 81(2018)
• Page Start: 142
• Page End: 148
• Publication Date: 2018-05
• Subjects: Pelvic floor -- Composite mesh -- Electrospinning -- Biocompatibility; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2018.02.030
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Composite mesh with different materials composition could compensate for the drawbacks brought by single component mesh. Coating a membrane layer on the surface of macroporous mesh is a common method for preparing composite medical mesh. Electrospinning and dipping methods were introduced to form the two kinds of membrane-coated PP meshes (electro-mesh and dip-mesh); several properties were measured based on subcutaneous implantation model in rat. The results revealed that continuous tissue ingrowth could be observed for electro-mesh only with evidences of strength increase (electro-mesh: 0 week − 13.1 ± 0.88 N, 2 week − 16.87 ± 1.39 N, 4 week − 22.04 ± 2.05 N) and thickness increase (electro-mesh: 0 week − 0.437 ± 0.023 mm, 2 week − 0.488 ± 0.025 mm, 4 week − 0.576 ± 0.028 mm). However, no tissues were observed for dip-mesh in the first 2 weeks, both on macroscopic level and microscopic level, proved by strength data (dip-mesh: 0 week − 13.36 ± 1.06 N, 2 week − 13.4 ± 1.33 N, 4 week – 18.61 ± 1.89 N) and thickness data (dip-mesh: 0 week − 0.439 ± 0.018 mm, 2 week − 0.439 ± 0.019 mm, 4 week − 0.502 ± 0.032 mm). Electro-mesh had larger surface area decrease (10.74 ± 1.22%) than that of dip-mesh (2.78 ± 0.52%). The adhesion level of electro-mesh (medium adhesion) was also higher than that of dip-mesh (mild adhesion). Even if showing differences in several properties, both meshes were similar under histological observation, with the ability to support fresh tissues ingrowth. Considering operation environment, electro-mesh seems more suitable than dip-mesh with a rapid tissue growing, medium adhesion rate for repairing pelvic floor defects.