Triterpene saponins with neuroprotective effects from a wild vegetable Aralia elata. (June 2018)

• Record Type: Journal Article
• Authors: Zhang, Yan; Wang, Wei; He, Huan; Song, Xiao-yu; Yao, Guo-dong; Song, Shao-jiang
• Is Part Of: Journal of functional foods. Volume 45(2018)
• Page Start: 313
• Page End: 320
• Publication Date: 2018-06
• Subjects: Aralia elata -- Triterpene saponins -- Neuroprotective -- Oxidative stress; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.04.026
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Taking it into consideration that Aralia elata is a functional food. Three novel triterpene saponins and twelve known ones were isolated. The structures were elucidated by physicochemical properties and spectral data. All isolates were investigated for their neuroprotective effects. Abstract: Aralia elata (Miq.) Seem. is a highly nutritious wild vegetable widely consumed in China, it can be made into salad, dumplings, pickles and soup for its fresh smell. In the phytochemical investigation of the constituents of Aralia elata, three new triterpene saponins (1 –3 ), named congmusaponin I, II and III, along with twelve known ones (4 –15 ) were isolated from the 70% EtOH extract of buds. Their structures were determined on the basis of spectroscopic analyses. All isolates were investigated for their neuroprotective effect on H2 O2 -induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y), and the new compound1 showed significant protective activity at 50 or 100 μM. The possible mechanism of compound1 was proved to be through inhibiting H2 O2 -induced apoptosis and fighting against oxidative stress in neurodegenerative disease. The current study suggests that triterpene saponins in Aralia elata may play an important role in the neuroprotective properties.