Exosomes and nanotubes: Control of immune cell communication. (February 2016)

• Record Type: Journal Article
• Authors: McCoy-Simandle, Kessler; Hanna, Samer J.; Cox, Dianne
• Is Part Of: International journal of biochemistry & cell biology. Volume 71(2016:Feb.)
• Page Start: 44
• Page End: 54
• Publication Date: 2016-02
• Subjects: APC Antigen presenting cell -- Cdc42 Cell division control protein 42 -- DC Dendritic cell -- EBV Epstein-Barr virus -- ESCRT Endosomal sorting complex required for transport -- HIV Human immunodeficiency virus -- ICAM-1 Intercellular adhesion molecule 1 -- IgA Immunoglobulin A -- IgG2 Immunoglobulin G2 -- IL-2 Interleukin 2 -- LAMP1 Lysosomal-associated membrane protein-1 -- LAMP2 Lysosomal-associated membrane protein-2 -- LFA-1 Leukocyte-function associated antigen 1 -- LST1 Leukocyte specific transcript 1 -- MHC Major histocompatibility complex -- miRNA MicroRNA -- MVB Multivesicular body -- NK Natural Killer -- NKG2D Natural-killer group 2, member D -- N-WASP Neuronal Wiskott-Aldrich syndrome protein -- Rac1 Ras-related C3 botulinum toxin substrate 1 -- RalA Ras-related protein Ral-A -- TCR T-cell receptor -- TGF Transforming growth factor -- TNFaip2 Tumor necrosis factor –α-induced protein -- TNTs Tunneling nanotubes -- WGA Wheat germ agglutinin; Tunneling nanotubes -- Cell–cell communication -- Multivesicular bodies -- Exosomes; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2015.12.006
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Cell–cell communication is critical to coordinate the activity and behavior of a multicellular organism. The cells of the immune system not only must communicate with similar cells, but also with many other cell types in the body. Therefore, the cells of the immune system have evolved multiple ways to communicate. Exosomes and tunneling nanotubes (TNTs) are two means of communication used by immune cells that contribute to immune functions. Exosomes are small membrane vesicles secreted by most cell types that can mediate intercellular communication and in the immune system they are proposed to play a role in antigen presentation and modulation of gene expression. TNTs are membranous structures that mediate direct cell-cell contact over several cell diameters in length (and possibly longer) and facilitate the interaction and/or the transfer of signals, material and other cellular organelles between connected cells. Recent studies have revealed additional, but sometimes conflicting, structural and functional features of both exosomes and TNTs. Despite the new and exciting information in exosome and TNT composition, origin and in vitro function, biologically significant functions are still being investigated and determined. In this review, we discuss the current field regarding exosomes and TNTs in immune cells providing evaluation and perspectives of the current literature.