Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices. (May 2018)

• Record Type: Journal Article
• Authors: Münker, T.J.A.G.; van de Vijfeijken, S.E.C.M.; Mulder, C.S.; Vespasiano, V.; Becking, A.G.; Kleverlaan, C.J.; Becking, A.G.; Dubois, L.; Karssemakers, L.H.E.; Milstein, D.M.J.; van de Vijfeijken, S.E.C.M.; Depauw, P.R.A.M.; Hoefnagels, F.W.A.; Vandertop, W.P.; Kleverlaan, C.J.; Münker, T.J.A.G.; Maal, T.J.J.; Nout, E.; Riool, M.; Zaat, S.A.J.
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 81(2018)
• Page Start: 168
• Page End: 172
• Publication Date: 2018-05
• Subjects: PMMA -- Sterilization -- Personalized medical device -- PSI -- Pre-treatment; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2018.01.033
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices. Graphical abstract: fx1 Highlights: Autoclavation is not suitable for PMMA-based medical devices. An increase in flexural strength (σ) resulted in decreased toughness (Kmax and Wf ). An increase in flexural strength (σ) resulted in increased impact strength (AcU ). An increase in toughness (Kmax and Wf ) resulted in decreased impact strength (AcU ). γ-Irradiation (26–29 kGy Cobalt-60) resulted in increased flexural strength (σ).