Development of a new ex vivo model for evaluation of endoscopic submucosal injection materials performance. (March 2018)

• Record Type: Journal Article
• Authors: Hirose, Ryohei; Nakaya, Takaaki; Naito, Yuji; Daidoji, Tomo; Yasuda, Hiroaki; Konishi, Hideyuki; Itoh, Yoshito
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 79(2018)
• Page Start: 219
• Page End: 225
• Publication Date: 2018-03
• Subjects: SIM submucosal injection material -- SEH submucosal elevation height -- EMR endoscopic mucosal resection -- ESD endoscopic submucosal dissection -- NS normal saline -- HA sodium hyaluronate; Endoscopic mucosal resection -- Normal saline -- Sodium hyaluronate -- Submucosal injection material -- ex vivo model; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2018.01.002
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Background and aims: Development of high-performance submucosal injection materials (SIMs) contribute to the advancement of endoscopic therapy for early-stage gastrointestinal neoplasms. This study aimed to develop a new ex vivo model that mimics the human gastrointestinal tract to evaluate the performance (the height and duration of the submucosal elevation) of various SIMs in detail. Methods: A new ex vivo model that applies a constant tension to the tested specimen (the porcine gastric specimen) was developed. SIMs were injected into the submucosa at the center or edge of the tested specimen, and submucosal elevation heights (SEHs) were measured over time. Results: The average value and standard deviation of SEH determined using the conventional model (the tested specimen was fixed with pins) were higher than those obtained using the new model, which showed that the new model could precisely measure the SEH of a given SIM. In addition, the performance (SEH) of SIMs decreased with increasing tension applied to the specimen, suggesting that the performance of SIMs deteriorates with the over-expansion of the gastrointestinal tract. The submucosal elevation formed at the specimen edge disappeared faster than that formed at the specimen's center. Conclusions: The proposed new ex vivo model allows accurate SEH measurement under uniform conditions and detailed comparison of the performances of various types of SIMs and can contribute to the development of high-performance materials. Graphical abstract: fx1 Highlights: A new evaluation model of submucosal injection materials (SIMs) was developed. The tension applied to the specimens affected the evaluation of the SIM performance. The new ex vivo model applied a constant tension to the tested specimen. The new ex vivo model could precisely measure the SIM performance.