The relationship between systemic iron homeostasis and erythropoiesis. Issue 6 (29th November 2017)

• Record Type: Journal Article
• Authors: Rishi, Gautam; Subramaniam, V. Nathan
• Is Part Of: Bioscience reports. Volume 37:Issue 6(2017)
• Publication Date: 2017-11-29
• Subjects: erythropoiesis -- erythropoietin -- hypoxia -- hepcidin -- iron metabolism -- transferrin receptors; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20170195
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis.