Association Between Tumor Size Kinetics and Survival in Patients With Urothelial Carcinoma Treated With Atezolizumab: Implication for Patient Follow‐Up. Issue 4 (5th July 2019)

• Record Type: Journal Article
• Authors: Tardivon, Coralie; Desmée, Solène; Kerioui, Marion; Bruno, René; Wu, Benjamin; Mentré, France; Mercier, François; Guedj, Jérémie
• Is Part Of: Clinical pharmacology & therapeutics. Volume 106:Issue 4(2019)
• Page Start: 810
• Page End: 820
• Publication Date: 2019-07-05
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.1450
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : We characterized the association between tumor size kinetics and survival in patients with advanced urothelial carcinoma treated with atezolizumab (anti‐programmed death‐ligand 1, Tecentriq) using a joint model. The model, developed on data from 309 patients of a phase II clinical trial, identified the time‐to‐tumor growth and the instantaneous changes in tumor size as the best on‐treatment predictors of survival. On the validation dataset containing data from 457 patients from a phase III study, the model predicted individual survival probability using 3‐month or 6‐month tumor size follow‐up data with an area under the receptor‐occupancy curve between 0.75 and 0.84, as compared with values comprised between 0.62 and 0.75 when the model included only information available at treatment initiation. Including tumor size kinetics in a relevant statistical framework improves the prediction of survival probability during immunotherapy treatment and may be useful to identify most‐at‐risk patients in "real‐time."