Histocompatibility locus antigens regions contribute to the ethnicity bias of Epstein‐Barr virus‐associated nasopharyngeal carcinoma in higher‐incidence populations. (23rd July 2019)

• Record Type: Journal Article
• Authors: Roy Chattopadhyay, Nabanita; Chakrabarti, Sudipta; Chatterjee, Koustav; Deb Roy, Sankar; Kumar Sahu, Sushil; Reddy, R. Rajendra; Das, Piyanki; Bijay Kanrar, Basab; Kumar Das, Ashok; Tsering, Sam; Puii, Zoren; Zomawia, Eric; Singh, Y. Indibor; Suryawanshi, Amol; Choudhuri, Tathagata
• Is Part Of: Scandinavian journal of immunology. Volume 90:Number 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-23
• Subjects: Epstein‐Barr virus -- histocompatibility locus antigens -- mongoloid races -- nasopharyngeal carcinoma -- polymorphism; Immunology -- Periodicals; 571.96
• DOI: 10.1111/sji.12796
• Languages: English
• ISSNs: 0300-9475

Abstract

Abstract: Nasopharyngeal carcinoma (NPC) is one the most confusing and rare malignancy in most part of the world with significantly high occurrence in some populations of Southeast Asia, North Africa and Alaska. Apart from the dietary and environmental factors, NPC is well‐associated with Epstein‐Barr virus (EBV) infection in these ethnic groups. However, the internal molecular mechanism(s) for such association in specific populations is not known till date. Polymorphisms in the genes of histocompatibility locus antigens (HLA) are reported in NPC, but association of any particular polymorphism with ethnicity is not established yet. Here, we report a set of HLA polymorphisms in EBV‐infected NPC samples from Northeast Indian population. These polymorphisms might play an important role for the lack of proper immune function against EBV infection and thus, eventually, for NPC generation in endemic populations like those of Northeast India.