Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial. (21st June 2019)

• Record Type: Journal Article
• Authors: Wang, H; Li, W; Zhang, D; Li, W; Wang, Z
• Is Part Of: Australian dental journal. Volume 64:Number 3(2019:Sep.)
• Page Start: 256
• Page End: 262
• Publication Date: 2019-06-21
• Subjects: Mechanical debridement -- peri‐implantitis -- photodynamic therapy -- randomized controlled trial; Dentistry -- Periodicals; Dentistry -- Periodicals; Dentisterie -- Australie -- Périodiques; Tandheelkunde; 617.6
• DOI: 10.1111/adj.12705
• Languages: English
• ISSNs: 0045-0421

Abstract

Abstract: Background: Photodynamic therapy (PDT) can be used for the management of peri‐implantitis. This study aimed to explore the efficacy and safety of PDT for peri‐implantitis in Chinese Han patients. Methods: This was a single‐centre, open‐label, randomized controlled trial of participants with peri‐implantitis treated at the Beijing Chao‐Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/mL; 3 min) and a 635‐nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm 2 ). The primary outcome was the decline in periodontal probing depth (PD) at 6 months. The secondary outcomes were peri‐implant plaque index (PLI), sulcular bleeding index (SBI), and clinical attachment loss (CAL). Results: PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3‐ and 6‐month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better ( P < 0.05 vs. controls). Conclusion: PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri‐implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.