Hybrid Soft Nanomaterials Composed of DNA Microspheres and Supramolecular Nanostructures of Semi‐artificial Glycopeptides. Issue 51 (21st August 2019)

• Record Type: Journal Article
• Authors: Higashi, Sayuri L.; Shibata, Aya; Kitamura, Yoshiaki; Hirosawa, Koichiro M.; Suzuki, Kenichi G. N.; Matsuura, Kazunori; Ikeda, Masato
• Is Part Of: Chemistry. Volume 25:Issue 51(2019)
• Page Start: 11955
• Page End: 11962
• Publication Date: 2019-08-21
• Subjects: DNA structures -- glycopeptides -- nanostructures -- self-assembly -- supramolecular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201902421
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Aqueous hybrid soft nanomaterials consisting of plural supramolecular architectures with a high degree of segregation (orthogonal coexistence) and precise hierarchy at the nano‐ and microscales, which are reminiscent of complex biomolecular systems, have attracted increasing attention. Remarkable progress has been witnessed in the construction of DNA nanostructures obtained by rational sequence design and supramolecular nanostructures of peptide derivatives through self‐assembly under aqueous conditions. However, orthogonal self‐assembly of DNA nanostructures and supramolecular nanostructures of peptide derivatives in a single medium has not yet been explored in detail. In this study, DNA microspheres, which can be obtained from three single‐stranded DNAs, and three different supramolecular nanostructures (helical nanofibers, straight nanoribbons, and flowerlike microaggregates) of semi‐artificial glycopeptides were simultaneously constructed in a single medium by a simple thermal annealing process, which gives rise to hybrid soft nanomaterials. Fluorescence imaging with selective staining of each supramolecular nanostructure uncovered the orthogonal coexistence of these structures with only marginal impact on their morphology. Additionally, the biostimuli‐responsive degradation propensity of each supramolecular architecture is retained, and this may allow the construction of active soft nanomaterials exhibiting intelligent biofunctions. Abstract : Orthogonal coexistence was disclosed for hybrid soft nanomaterials composed of biomolecule‐based supramolecular architectures (DNA microspheres, green) and supramolecular nanostructures of semi‐artificial glycopeptides (magenta; see figure). The hybrid soft nanomaterials constructed by simple thermal annealing retain the biostimuli‐responsive properties of the individual supramolecular architectures, which could provide useful insights into the development of biofunctional soft nanomaterials.