Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival. Issue 10 (24th July 2019)

• Record Type: Journal Article
• Authors: Rajappa, Suhas K.; Maheshwari, Udip; Ram, Dharma; Koyyala, Venkata P. B.; Mandal, Ghanashyam; Goyal, Sumit; Kumar, Rajeev; Dewan, Ajay K.
• Is Part Of: Head & neck. Volume 41:Issue 10(2019)
• Page Start: 3577
• Page End: 3583
• Publication Date: 2019-07-24
• Subjects: adjuvant therapy -- oral cavity cancer -- prognostic factors -- radiation -- survival; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25882
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Early oral cavity cancer has good prognosis but recurrence in them is still not uncommon. There is no general consensus on the prognostic factors and adjuvant therapy that would have a significant impact on survival. Methods: A retrospective analysis of early oral cavity cancer patients during the time period 2009‐2017. The data regarding demographics, histopathological features, and recurrence patterns were collected and analyzed. Results: Depth of invasion (DOI) was the most important prognostic factor among all the factors analyzed. Further analysis showed that addition of adjuvant radiotherapy for patients with DOI >5 mm did not show survival benefits ( P = .73). Another subset analysis of patients with DOI >10 mm also did not show any survival advantage with adjuvant therapy P = .24. Conclusion: There is no benefit of adding adjuvant RT in patients with DOI > 5 mm or in patients who were upstaged to T3 based only on DOI.