Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections. (19th July 2019)

• Record Type: Journal Article
• Authors: Qu, Changbo; Zhang, Shaoshi; Li, Yang; Wang, Yijin; Peppelenbosch, Maikel P.; Pan, Qiuwei
• Is Part Of: Reviews in medical virology. Volume 29:Number 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-19
• Subjects: hepatitis virus -- mitochondria -- pathogenesis -- treatment; Medical virology -- Periodicals; Review Literature -- Periodicals; Virus Diseases -- Periodicals; Viruses -- Periodicals; 616.0194
• DOI: 10.1002/rmv.2075
• Languages: English
• ISSNs: 1052-9276

Abstract

Summary: Hepatitis virus infections affect a large proportion of the global population. The host responds rapidly to viral infection by orchestrating a variety of cellular machineries, in particular, the mitochondrial compartment. Mitochondria actively regulate viral infections through modulation of the cellular innate immunity and reprogramming of metabolism. In turn, hepatitis viruses are able to modulate the morphodynamics and functions of mitochondria, but the mode of actions are distinct with respect to different types of hepatitis viruses. The resulting mutual interactions between viruses and mitochondria partially explain the clinical presentation of viral hepatitis, influence the response to antiviral treatment, and offer rational avenues for novel therapy. In this review, we aim to consider in depth the multifaceted interactions of mitochondria with hepatitis virus infections and emphasize the implications for understanding pathogenesis and advancing therapeutic development.