Factors for predicting reversion from mild cognitive impairment to normal cognition: A meta‐analysis. (4th July 2019)

• Record Type: Journal Article
• Authors: Xue, HuiPing; Hou, Ping; Li, YongNan; Mao, Xin'e; Wu, LinFeng; Liu, YongBing
• Is Part Of: International journal of geriatric psychiatry. Volume 34:Number 10(2019)
• Page Start: 1361
• Page End: 1368
• Publication Date: 2019-07-04
• Subjects: mild cognitive impairment -- normal cognition -- reversion -- factor; Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.5159
• Languages: English
• ISSNs: 0885-6230

Abstract

Abstract : Objective: Subjects with mild cognitive impairment (MCI) may revert to normal cognition (NC), but predictive factors are under study. We therefore sought to identify factors which could help in predicting reversion from MCI to NC. Methods: Relevant studies were retrieved from PubMed, EMBASE, Cochrane Library, MEDLINE, Web of Science, EBSCO, and OVID. According to the inclusion and exclusion criteria, high‐quality assessments of relevant literatures were conducted, followed by data extraction and meta‐analysis with Stata 12.0 software. Results: A total of 17 studies with 6829 participants were included in the meta‐analysis. The overall reversion rate is 27.57%. Positive predictive factors were found in younger age (SMD = −0.345, 95% CI, −0.501 to −0.189), higher education level (SMD = 0.337, 95% CI, 0.117‐0.558), no APOE ε4 allele (OR = 0.728, 95% CI, 0.575‐0.922), no hypertension (OR = 0.826, 95% CI, 0.692‐0.987), no stroke (OR = 0.696, 95% CI, 0.507‐0.953), and higher Mini‐Mental State Examination (MMSE) score (SMD = 0.707, 95% CI, 0.461‐0.953). Conclusion: Individuals who are at young age, have higher education level and MMSE score, and have no APOEe4 allele, no hypertension, and no stroke had a high probability to revert from MCI to NC.