Accuracy of deep learning to differentiate the histopathological grading of meningiomas on MR images: A preliminary study. Issue 4 (21st March 2019)

• Record Type: Journal Article
• Authors: Banzato, Tommaso; Causin, Francesco; Della Puppa, Alessandro; Cester, Giacomo; Mazzai, Linda; Zotti, Alessandro
• Is Part Of: Journal of magnetic resonance imaging. Volume 50:Issue 4(2019)
• Page Start: 1152
• Page End: 1159
• Publication Date: 2019-03-21
• Subjects: meningioma -- deep learning -- apparent diffusion coefficient -- postcontrast -- grading; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.26723
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: Grading of meningiomas is important in the choice of the most effective treatment for each patient. Purpose: To determine the diagnostic accuracy of a deep convolutional neural network (DCNN) in the differentiation of the histopathological grading of meningiomas from MR images. Study Type: Retrospective. Population: In all, 117 meningioma‐affected patients, 79 World Health Organization [WHO] Grade I, 32 WHO Grade II, and 6 WHO Grade III. Field Strength/Sequence: 1.5 T, 3.0 T postcontrast enhanced T1 W (PCT1 W), apparent diffusion coefficient (ADC) maps (b values of 0, 500, and 1000 s/mm 2 ). Assessment: WHO Grade II and WHO Grade III meningiomas were considered a single category. The diagnostic accuracy of the pretrained Inception‐V3 and AlexNet DCNNs was tested on ADC maps and PCT1 W images separately. Receiver operating characteristic curves (ROC) and area under the curve (AUC) were used to asses DCNN performance. Statistical Test: Leave‐one‐out cross‐validation. Results: The application of the Inception‐V3 DCNN on ADC maps provided the best diagnostic accuracy results, with an AUC of 0.94 (95% confidence interval [CI], 0.88–0.98). Remarkably, only 1/38 WHO Grade II–III and 7/79 WHO Grade I lesions were misclassified by this model. The application of AlexNet on ADC maps had a low discriminating accuracy, with an AUC of 0.68 (95% CI, 0.59–0.76) and a high misclassification rate on both WHO Grade I and WHO Grade II–III cases. The discriminating accuracy of both DCNNs on postcontrast T1 W images was low, with Inception‐V3 displaying an AUC of 0.68 (95% CI, 0.59–0.76) and AlexNet displaying an AUC of 0.55 (95% CI, 0.45–0.64). Data Conclusion: DCNNs can accurately discriminate between benign and atypical/anaplastic meningiomas from ADC maps but not from PCT1 W images. Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1152–1159.