Anti-inflammatory diterpenes from the fruits of Vitex trifolia L. var. simplicifolia Cham. Issue 10 (3rd October 2019)

• Record Type: Journal Article
• Authors: Fang, Shi-Ming; Liu, Rui; Li, Lin; Yao, Jin-Long; Liu, Er-Wei; Fan, Guan-Wei; Zhang, Han; Gao, Xiu-Mei
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 10(2019)
• Page Start: 985
• Page End: 991
• Publication Date: 2019-10-03
• Subjects: Verbenaceae -- Vitex trifolia L. var. simplicifolia -- labdane-type diterpene -- anti-inflamatory activity -- nuclear factor-kappa B; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1482881
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new labdane-type diterpenes, named viterotulin C (1 ) and vitexilactone D (2 ), together with five known diterpenes (3–7 ), were isolated from the fruits of Vitex trifolia L. var. simplicifolia Cham. Their structures were elucidated by detailed analysis of spectroscopic data. All the compounds were evaluated for their inhibitory effects on nuclear factor-kappa B (NF-κB) pathway in HEK 293 cell line. These compounds presented inhibition on TNF-α-induced NF-κB activation, with inhibition rates ranging from 42.52 ± 10.69% to 68.86 ± 10.76% at the concentration of 50 μM. Abstract :