Aryl-tetralin-type lignan isolated from Sanguisorba officinalis. Issue 10 (3rd October 2019)

• Record Type: Journal Article
• Authors: Wang, Li-Na; Qin, Ling-Ling; He, Jun-Lin; Li, Xiao-Hua; Cao, Zhi-Xing; Gu, Yu-Cheng; Deng, Fang; Deng, Yun
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 10(2019)
• Page Start: 999
• Page End: 1004
• Publication Date: 2019-10-03
• Subjects: Rosaceae -- Sanguisorba officinalis -- structural elucidation -- aryl-tetralin-type lignan; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1487957
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three aryl-tetralin-type lignans, including 2 previously undescribed compounds, were isolated from the root of Sanguisorba officinalis . The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analyses and mass spectrometry. Experimental and calculated ECD were used to determine the absolute configurations. The isolated compounds were evaluated for cytotoxicity against two cell lines (MV4-11 and MDA-MB-231) and compound1 exhibited moderate growth inhibition against MDA-MB-231 cell line with IC50 value of 15.76 μM. Abstract :