An erythrocyte membrane coated mimetic nano-platform for chemo-phototherapy and multimodal imaging. Issue 48 (4th September 2019)

• Record Type: Journal Article
• Authors: Xiao, Feng; Fan, Jialong; Tong, Chunyi; Xiao, Chang; Wang, Zhou; Liu, Bin; Daniyal, Muhammad; Wang, Wei
• Is Part Of: RSC advances. Volume 9:Issue 48(2019)
• Page Start: 27911
• Page End: 27926
• Publication Date: 2019-09-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05867b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The tumor variability and low efficiency associated with conventional chemical drugs provide an impetus to develop drug-carrying systems with targeted accumulation and controllable release behavior. Abstract : The tumor variability and low efficiency associated with conventional chemical drugs provide an impetus to develop drug-carrying systems with targeted accumulation and controllable release behavior. Herein, DOX-loaded Prussian blue (PB) nano-composites are developed after coating with erythrocyte membrane (EM) and modifying with folic acid (FA). In these nano-composites, PB nanoparticles mixture with different shapes were adopted to improve the photothermal performance, which is highly helpful for cancer photothermal ablation and controllable drug release. In addition, the nano-composites were endowed with high biocompatibility, immune evading capacity, pH-/photo-responsive release behavior, and markedly prolonged blood circulation time, which was reflected by a 99.6% cervical tumor growth inhibition value (TGI) in vivo . Meanwhile, they functioned as multimodal bioimaging agents for photothermal, fluorescence, and photoacoustic imaging of tumors. The reported strategy can be applied for personalized therapy of various tumors by modifying the tumor-targeting molecule on the surface of nanoparticles.