Development of improved dual-diazonium reagents for faster crosslinking of tobacco mosaic virus to form hydrogels. Issue 50 (17th September 2019)

• Record Type: Journal Article
• Authors: Ma, Dejun; Chen, Zhuoyue; Yi, Long; Xi, Zhen
• Is Part Of: RSC advances. Volume 9:Issue 50(2019)
• Page Start: 29070
• Page End: 29077
• Publication Date: 2019-09-17
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05630k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Improved dual-diazonium reagents were developed for more efficient crosslinking of tobacco mosaic virus to form hydrogels. Abstract : New bench-stable reagents with two diazonium sites were designed and synthesized for protein crosslinking. Because of the faster diazonium-tyrosine coupling reaction, hydrogels from the crosslinking of tobacco mosaic virus and the reagentDDA-3 could be prepared within 1 min at room temperature. Furthermore, hydrogels with the introduction of disulfide bonds via DDA-4 could be chemically degraded by dithiothreitol. Our results provided a facile approach for the direct construction of virus-based hydrogels.