Synthesis of a 1, 2-cis-indoxyl galactoside as a chromogenic glycosidase substrate. Issue 48 (9th September 2019)

• Record Type: Journal Article
• Authors: Nagata, Sakuto; Tomida, Hirotaka; Iwai-Hirose, Haruka; Tanaka, Hide-Nori; Ando, Hiromune; Imamura, Akihiro; Ishida, Hideharu
• Is Part Of: RSC advances. Volume 9:Issue 48(2019)
• Page Start: 28241
• Page End: 28247
• Publication Date: 2019-09-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05797h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The highly challenging synthesis of a 1, 2- cis -indoxyl galactoside was first achieved. Abstract : A synthetically challenging 1, 2- cis -indoxyl galactoside, X-α-galactoside, was first prepared in this study using a cyclic ketone indoxyl acceptor and a glycosyl trichloroacetimidate donor to produce an enol glycoside and a 4, 6- O -di- tert -butylsilylene-protected galactosyl donor to complete the synthesis. The target compound shows enzyme activity in the presence of α-galactosidase.