Recent advances in the synthesis of carbazoles from indoles. Issue 36 (9th September 2019)

• Record Type: Journal Article
• Authors: Aggarwal, Trapti; Sushmita, ; Verma, Akhilesh K.
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 36(2019)
• Page Start: 8330
• Page End: 8342
• Publication Date: 2019-09-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01381d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Synthesis of carbazoles using indoles as precursors through CH activation/annulation. Abstract : Carbazoles are privileged nitrogen heterocycles that are present in a wide range of natural products, pharmaceuticals, and functional materials. Due to their wide application, various synthetic strategies are available in the literature using substituted amines or indoles as a substrate. Thus, this review comprehensively highlights the (2015–2019) article that focuses on the synthesis of carbazoles derived from an indole-template through transition-metal catalyzed C–H functionalization, metal-free cyclization, three-component reaction, and electrophilic iodocyclizations. The synthetic strategies described in this review provided diversely substituted carbazoles and few of them have profound pharmacological activity.