Is brain connectome research the future frontier for subjective cognitive decline? A systematic review. Issue 10 (October 2019)

• Record Type: Journal Article
• Authors: Lazarou, Ioulietta; Nikolopoulos, Spiros; Dimitriadis, Stavros I.; (Yiannis) Kompatsiaris, Ioannis; Spilioti, Martha; Tsolaki, Magda
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 10(2019:Oct.)
• Page Start: 1762
• Page End: 1780
• Publication Date: 2019-10
• Subjects: AD Alzheimer's Disease -- ACC Anterior Cingulate Cortex -- avDMN Anterior Ventral DMN -- CAU Caudate nucleus -- CUN Cuneus -- DMN Default Mode Network -- DAN Dorsal Attention Network -- FC Functional Connectivity -- GMN Gray Matter Networks -- HC Healthy Controls -- HP Hippocampus -- IPC Inferior Parietal Cortex -- IPG Inferior Parietal Gyrus -- IPL Inferior Parietal Lobule -- mPFC Medial Prefrontal Cortex -- MTL Medial Temporal Lobe -- MTMS Medial Temporal Memory system -- MVN Medial Visual Network -- MCI Mild Cognitive Impairment -- PCC Posterior Cingulate Cortex -- pDMN Posterior Default Mode Network -- PUN Precuneus -- PUT Putamen -- ROI Region of Interest -- RSC Retrosplenial Cortex -- SCD Subjective Cognitive Decline -- SMA Supplementary Motor Area -- SL Synchronization Likelihood -- THA Thalamus -- vmPFC Ventral Medial Prefrontal Cortex -- WMN White Matter Network; Alzheimer's disease -- Network analysis -- Subjective cognitive decline -- Mild cognitive impairment -- Neuroimaging; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.07.004
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Network disorganization in people with Subjective Cognitive Decline (SCD) was found in the majority of the reported studies. Brain connectome in SCD is disrupted in a similar way as in mild cognitive impairment compared to Healthy Controls. Small-world and rich-club were preserved in SCDs while aberrant local connections were observed. Abstract: Objective: We performed a systematic literature review on Subjective Cognitive Decline (SCD) in order to examine whether the resemblance of brain connectome and functional connectivity (FC) alterations in SCD with respect to MCI, AD and HC can help us draw conclusions on the progression of SCD to more advanced stages of dementia. Methods: We searched for studies that used any neuroimaging tool to investigate potential differences/similarities of brain connectome in SCD with respect to HC, MCI, and AD. Results: Sixteen studies were finally included in the review. Apparent FC connections and disruptions were observed in the white matter, default mode and gray matter networks in SCD with regards to HC, MCI, and AD. Interestingly, more apparent connections in SCD were located over the posterior regions, while an increase of FC over anterior regions was observed as the disease progressed. Conclusions: Elders with SCD display a significant disruption of the brain network, which in most of the cases is worse than HC across multiple network parameters. Significance: The present review provides comprehensive and balanced coverage of a timely target research activity around SCD with the intention to identify similarities/differences across patient groups on the basis of brain connectome properties.