Complications after liver surgery: a benchmark analysis. Issue 9 (September 2019)

• Record Type: Journal Article
• Authors: Bagante, Fabio; Ruzzenente, Andrea; Beal, Eliza W.; Campagnaro, Tommaso; Merath, Katiuscha; Conci, Simone; Akgül, Ozgür; Alexandrescu, Sorin; Marques, Hugo P.; Lam, Vincent; Shen, Feng; Poultsides, George A.; Soubrane, Olivier; Martel, Guillaume; Iacono, Calogero; Guglielmi, Alfredo; Pawlik, Timothy M.
• Is Part Of: HPB. Volume 21:Issue 9(2019)
• Page Start: 1139
• Page End: 1149
• Publication Date: 2019-09
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2018.12.013
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: The best achievable short-term outcomes after liver surgery have not been identified. Several factors may influence the post-operative course of patients undergoing hepatectomy increasing the risk of post-operative complications. We sought to identify risk-adjusted benchmark values [BMV] for liver surgery. Methods: The National Surgery Quality Improvement Program (NSQIP) database was used to develop Bayesian models to estimate risk-adjusted BMVs for overall and liver related (post-hepatectomy liver failure [PHLF], biliary leakage [BL]) complications. A separate international multi-institutional database was used to validate the risk-adjusted BMVs. Results: Among the 11, 243 patients included in the NSQIP database, the incidence of complications, PHLF, and BL was 36%, 5%, and 8%, respectively. The risk-adjusted BMVs for complication (range, 16–72%), PHLF (range, 1%–20%), and BL (range, 4%–22%) demonstrated a high variability based on patients characteristics. When tested using an international database including nine institutes, the risk-adjusted BMVs for complications ranged from 26% (Institute-4) to 43% (Institute-1), BMVs for PHLF between 3% (Institute-3) and 12% (Institute-5), while BMVs for BL ranged between 5% (Institute-4) and 9% (Institute-7). Conclusions: Multiple factors influence the risk of complications following hepatectomy. Risk-adjusted BMVs are likely much more applicable and appropriate in assessing "acceptable" benchmark outcomes following liver surgery.