Impaired visuospatial attention revealed by theta- and beta-band cortical activities in idiopathic REM sleep behavior disorder patients. Issue 10 (October 2019)

• Record Type: Journal Article
• Authors: Her, Seongjin; Cha, Kwang Su; Choi, Jeong Woo; Kim, Hyun; Byun, Jung-Ick; Sunwoo, Jun-Sang; Kim, Tae-Joon; Lim, Jung-Ah; Jung, Ki-Young; Kim, Kyung Hwan
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 10(2019:Oct.)
• Page Start: 1962
• Page End: 1970
• Publication Date: 2019-10
• Subjects: REM sleep behavior disorder -- Posner cueing task -- Event-related potentials -- Event-related spectral perturbation -- Cognitive dysfunction; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.07.030
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Attention dysfunction in idiopathic REM sleep behavior disorder (iRBD) patients was studied by event-related EEG analysis. Normal cortical activity reflecting 'inhibition of return' (IOR) was absent in iRBD patients. The absence of IOR in iRBD may imply dysfunctions in visuoperceptual processing and motor control. Abstract: Objectives: Idiopathic REM sleep behavior disorder (iRBD) patients are susceptible to cognitive deficits, especially attention dysfunction. The objective of this study is to elucidate the neural mechanism of the dysfunction in attention known as 'inhibition of return' (IOR) in iRBD patients based on an analysis of oscillatory cortical activity during a selective attention task. Methods: Event-related potentials (ERPs) were recorded from iRBD patients and normal control subjects while performing a Posner task. The differences in N1 ERP and theta- and beta-bands event-related spectral perturbations (ERSPs) between valid and invalid stimuli were compared between groups. Results: The N1 amplitude was significantly higher for the invalid stimuli in controls, while the valid-invalid difference was not significant in iRBD patients. The valid-invalid differences in ERSPs were prominent in controls at ∼100–400 ms for the theta-band and ∼200–400 ms for the beta-band, and the valid-invalid differences in ERSPs were not significant in the iRBD patients. Conclusion: The results demonstrated that valid-invalid differences in neural activity were absent in iRBD patients, and these neural findings were in accord with the behavioral results. Significance: Our findings imply impairment in sensory-perceptual processing mediated by attentional control and response inhibition in early-stage iRBD before clinical neurodegeneration.