Mapping the protein–protein and genetic interactions of cancer to guide precision medicine. (February 2019)

• Record Type: Journal Article
• Authors: Bouhaddou, Mehdi; Eckhardt, Manon; Chi Naing, Zun Zar; Kim, Minkyu; Ideker, Trey; Krogan, Nevan J
• Is Part Of: Current opinion in genetics & development. Volume 54(2019)
• Page Start: 110
• Page End: 117
• Publication Date: 2019-02
• Subjects: Genetics -- Periodicals; Developmental biology -- Periodicals; Developmental genetics -- Periodicals; 576.5
• DOI: 10.1016/j.gde.2019.04.005
• Languages: English
• ISSNs: 0959-437X

Abstract

Abstract: Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of 'hallmark cancer pathways'. However, unraveling how sets of mutated proteins in these and other pathways hijack pro-proliferative signaling networks and dictate therapeutic responsiveness remains challenging. Here, we show that cancer driver protein–protein interactions are enriched for additional cancer drivers, highlighting the power of physical interaction maps to explain known, as well as uncover new, disease-promoting pathway interrelationships. We hypothesize that by systematically mapping the protein–protein and genetic interactions in cancer—thereby creating Cancer Cell Maps—we will create resources against which to contextualize a patient's mutations into perturbed pathways/complexes and thereby specify a matching targeted therapeutic cocktail.