Synthesis, characterization and antibacterial activity of aluminum doped zinc oxide. (2019)

• Record Type: Journal Article
• Authors: Saxena, Varun; Pandey, Lalit M.
• Is Part Of: Materials today. Volume 18:Part 3(2019)
• Page Start: 1388
• Page End: 1400
• Publication Date: 2019
• Subjects: Nanoantibiotic -- AZO -- Antibacterial activity -- Biocompatibility; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2019.06.605
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Recent era demands the antibacterial agents to reduce the side effects and other associated problems with conventional antibiotics. Here, we report the synthesis of Al doped ZnO (AZO) via precipitation method and its utilization as nanoantibiotic. ZnO nanoparticles own decent bactericidal activity against a broad spectrum of bacterial species. However, the bactericidal efficiency of ZnO remains a major challenge. Therefore, to enhance the antibacterial efficiency of ZnO, Al was doped in ZnO. The synthesized AZO nanorods were characterized by various physical and chemical techniques such as X-Ray Diffraction (XRD), RAMAN spectroscopy, Fourier transformation infrared (FTIR) spectroscopy, Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-Ray Spectroscopy (EDS). A hexagonal wurtzite structure of both ZnO and AZO was confirmed using XRD, which was further supported by RAMAN and FTIR spectra. The synthesized nanorods were also evaluated for their cyto-compatibility and antimicrobial activity. The antibacterial activity was examined against clinically significant Enterococcus hirae (Gram positive) and Escherichia coli (Gram negative) bacteria via disc diffusion method. The zone of inhibition for AZO was found to be 10.19± 0.04 mm and 10.20±0.02 mm against E.coli and E.hirae, respectively. The antibacterial activity of AZO was found to be enhanced as compared to ZnO and was governed by electrostatic interactions. The synthesized nanorods exhibited excellent cyto-compatibility with >93% cell viability after 6 days. Hence, this study recommended AZO as an effective nanoantibiotic, which can be further explored for antifungal, drug delivery, tissue engineering and other biomedical applications.