Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue. Issue 37 (11th June 2019)

• Record Type: Journal Article
• Authors: Cotler, Max J.; Rousseau, Erin B.; Ramadi, Khalil B.; Fang, Joshua; Graybiel, Ann M.; Langer, Robert; Cima, Michael J.
• Is Part Of: Small. Volume 15:Issue 37(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-06-11
• Subjects: borosilicate -- drug delivery -- needle steering -- neuroengineering; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201901459
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Enhanced understanding of neuropathologies has created a need for more advanced tools. Current neural implants result in extensive glial scarring and are not able to highly localize drug delivery due to their size. Smaller implants reduce surgical trauma and improve spatial resolution, but such a reduction requires improvements in device design to enable accurate and chronic implantation in subcortical structures. Flexible needle steering techniques offer improved control over implant placement, but often require complex closed‐loop control for accurate implantation. This study reports the development of steerable microinvasive neural implants (S‐MINIs) constructed from borosilicate capillaries (OD = 60 µm, ID = 20 µm) that do not require closed‐loop guidance or guide tubes. S‐MINIs reduce glial scarring 3.5‐fold compared to prior implants. Bevel steered needles are utilized for open‐loop targeting of deep‐brain structures. This study demonstrates a sinusoidal relationship between implant bevel angle and the trajectory radius of curvature both in vitro and ex vivo. This relationship allows for bevel‐tipped capillaries to be steered to a target with an average error of 0.23 mm ± 0.19 without closed‐loop control. Polished microcapillaries present a new microinvasive tool for chronic, predictable targeting of pathophysiological structures without the need for closed‐loop feedback and complex imaging. Abstract : Bevel‐tipped microcapillary brain implants are predictably guided to target sites using needle steering techniques and an empirical relationship between tip bevel angle and insertion trajectory. Needle guidance allows for improved targeting of pathophysiological microstructures with minimal long‐term scarring in the brain and potential applications in other solid organs.