Hemocompatibility of different burn wound dressings. Issue 5 (13th June 2019)

• Record Type: Journal Article
• Authors: Denzinger, Markus; Held, Manuel; Scheffler, Hanna; Haag, Hanna; Nussler, Andreas K.; Wendel, Hans Peter; Schlensak, Christian; Daigeler, Adrien; Krajewski, Stefanie
• Is Part Of: Wound repair and regeneration. Volume 27:Issue 5(2019)
• Page Start: 470
• Page End: 476
• Publication Date: 2019-06-13
• Subjects: Wound healing -- Periodicals; Regeneration (Biology) -- Periodicals; 617.14
• DOI: 10.1111/wrr.12739
• Languages: English
• ISSNs: 1067-1927

Abstract

Abstract: A variety of wound dressing are available for burns. Furthermore, although their impacts on wound healing have been studied sufficiently, their effects on blood remain unclear. Meanwhile, this aspect is extremely important, since blood interacts with the wound dressing, especially in extensive burn injuries. Therefore, the aim of this study is to evaluate the hemocompatibility and immunogenicity of different burn wound dressings. Accordingly, human whole blood ( n = 5) was anticoagulated with heparin, treated with different wound dressings and incubated at 37°C for 30 minutes. Different parameters for coagulation and hemocompatibility were evaluated before and after incubation. Consequently, Jelonet, Xenoderm, and Matriderm showed higher TAT‐III concentrations, Jelonet, Xenoderm, EZ Derm, and Matriderm were higher β‐thromboglobulin; EZ Derm and Burntec showed higher SC5b‐9 concentrations after incubation with whole blood. Our ex vivo study provided initial insights into the hemocompatibility and immunogenicity of different burn wound dressings. Moreover, Xenografts (Xenoderm and EZ Derm), Jelonet and Matriderm showed a hemostyptic effect, while EZ Derm and Burntec activated the complement system. Therefore, further studies must be conducted to analyze the possible effects in vivo.