Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network. Issue 17 (30th July 2019)

• Record Type: Journal Article
• Authors: von Blume, Julia; Hausser, Angelika
• Is Part Of: FEBS letters. Volume 593:Issue 17(2019)
• Page Start: 2412
• Page End: 2427
• Publication Date: 2019-07-30
• Subjects: diacylglycerol -- secretory cargo sorting -- sphingolipids -- trafficking -- trans‐Golgi network; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13552
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : In eukaryotic cells, the trans‐Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid–lipid and lipid–protein interactions contributes to these key functions. This review addresses the role of lipids at the TGN with a particular emphasis on sphingolipids and diacylglycerol. We further highlight how these lipids couple secretory cargo sorting and trafficking for spatiotemporal coordination of protein transport to the plasma membrane. Abstract :