Serum endocan levels, carotid intima-media thickness and microalbuminuria in patients with newly diagnosed hypertension. (17th November 2019)

• Record Type: Journal Article
• Authors: Oktar, Sevil Fisekci; Guney, Ibrahim; Eren, Sayeste Akkan; Oktar, Levent; Kosar, Kenan; Buyukterzi, Zafer; Alkan, Ender; Biyik, Zeynep; Erdem, Said Sami
• Is Part Of: Clinical and experimental hypertension. Volume 41:Number 8(2019)
• Page Start: 787
• Page End: 794
• Publication Date: 2019-11-17
• Subjects: Endocan -- hypertension -- microalbuminuria; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.1080/10641963.2019.1652632
• Languages: English
• ISSNs: 1064-1963

Abstract

ABSTRACT: Background : Endocan is a particular protein of endothelial cells. The purpose of this study was to determine the relationship of serum endocan levels with carotid intima-media thickness (cIMT), inflammation, and microalbuminuria in patients with newly-diagnosed hypertension. Materials-Methods : This prospective study included 61 patients with newly-diagnosed hypertension (HT) and 30 controls. Endocan, microalbuminuria and cIMT measurements were taken from all patients. Results : The serum endocan levels, the mean cIMT and microalbuminuria levels of patients with HT were significantly higher than those of the control group ( p < .0001, p = .015 and p < .001, respectively). Conclusion : We found that endocan levels were increased in our study. This increase in endocan levels shows a relation with cIMT and microalbuminuria, which are associated with endothelial dysfunction.