Tetrabromobisphenol A induced oxidative stress and genotoxicity in fish Channa punctatus. (2nd November 2019)

• Record Type: Journal Article
• Authors: Sharma, Prince; Chadha, Pooja; Saini, Harvinder Singh
• Is Part Of: Drug and chemical toxicology. Volume 42:Number 6(2019)
• Page Start: 559
• Page End: 564
• Publication Date: 2019-11-02
• Subjects: Tetrabromobisphenol A -- Channa punctatus -- oxidative stress -- genotoxicity; Toxicology -- Periodicals; Drugs -- Toxicology -- Periodicals; Toxicology, Experimental -- Periodicals; 615.9005
• DOI: 10.1080/01480545.2018.1441864
• Languages: English
• ISSNs: 0148-0545

Abstract

Abstract: Tetrabromobisphenol A (TBBPA) is the most widely used brominated flame retardant and its increased use in common products such as plastics, electronic equipment, etc., has raised concern about its ecotoxicity. The present study was conducted to investigate the oxidative stress and genotoxic potential of TBBPA on fresh water fish Channa punctatus by measuring malondialdehyde level and DNA damage, respectively. Fish were exposed to 5.09 mg/l (1/2 of LC50 ) of TBBPA along with positive (acetone) and negative controls (water) for 96 h. The blood samples were collected at 24, 48, 72 and 96 h post exposure. The results of the study showed significantly increased oxidative stress and DNA damage in the exposed groups as compared to controls. The effect of duration is also found to be significant. The findings of the study would be helpful in risk assessment of TBBPA-induced oxidative stress and genotoxicity among aquatic organisms.