Relationship between an indel mutation within the SIRT4 gene and growth traits in Chinese cattle. Issue 4 (2nd October 2019)

• Record Type: Journal Article
• Authors: Zhang, Qingfeng; Jin, Yunyun; Jiang, Fugui; Cheng, Haijian; Wang, Yafang; Lan, Xianyong; Song, Enliang
• Is Part Of: Animal biotechnology. Volume 30:Issue 4(2019)
• Page Start: 352
• Page End: 357
• Publication Date: 2019-10-02
• Subjects: Cattle -- SIRT4 -- insertion/deletion (indel) -- growth traits -- association; Animal biotechnology -- Periodicals; Animals, Domestic -- genetics -- Periodicals; Animals, Genetically Modified -- Periodicals; 660.6
• DOI: 10.1080/10495398.2018.1520716
• Languages: English
• ISSNs: 1049-5398

Abstract

Abstract: Growth traits are mainly determined by genetic factors. SIRT4, a class II sirtuin, predominantly acts as an ADP-ribosyltransferase and inhibits fatty acid oxidation. In this study, a total of 1005 cattle belonging to five indigenous Chinese breeds were used to evaluate the relationship between the potential insertions/deletions (indels) within the SIRT4 gene and growth traits. The results revealed that only one intronic variation was present, which showed Hardy–Weinberg equilibrium ( p > 0.05) in all the populations. The relationship analyses indicated that this indel was significantly associated with growth traits ( p < 0.05), implying that SIRT4 significantly affects the growth traits. Therefore, the deletion mutation within the SIRT4 gene could be considered as a molecular marker to screen for growth traits in the cattle industry.