Genetic effect and combined genotype effect of ESR, FSHβ, CTNNAL1 and miR-27a loci on litter size in a Large White population. Issue 4 (2nd October 2019)

• Record Type: Journal Article
• Authors: Pang, Panfei; Li, Zhenzhu; Hu, Hua; Wang, Lei; Sun, Hua; Mei, Shuqi; Li, Fenge
• Is Part Of: Animal biotechnology. Volume 30:Issue 4(2019)
• Page Start: 287
• Page End: 292
• Publication Date: 2019-10-02
• Subjects: Pig -- litter size -- genetic marker -- MBLUP; Animal biotechnology -- Periodicals; Animals, Domestic -- genetics -- Periodicals; Animals, Genetically Modified -- Periodicals; 660.6
• DOI: 10.1080/10495398.2018.1486322
• Languages: English
• ISSNs: 1049-5398

Abstract

Abstract: To select new Large White line with high number of piglets born, genotypes of estrogen receptor ( ESR ), the follicle stimulating hormone β subunit ( FSH β), catenin alpha like 1 ( CTNNAL1 ) and miR-27a were tested in 472 Large White sows. The associations of different genotypes with litter size traits were also studied. The results showed ESR BB and FSHβ BB sows produced 0.41–1.49 more pigs per litter ( p < .05) for total number born (TNB) and number born alive (NBA) than did other corresponding genotypes. TNB of CTNNAL1 CG sows is 0.50 more pigs per litter ( p < .05) than that of CTNNAL1 GG sows with the dominance effect of 0.25 pigs per litter ( p < .05). miR-27a BB sows had a less estimated breeding value (EBV) to TNB and had a more number of mummified pigs (NM) than did miR-27a AA or miR-27a AB sows ( p < .05). Therefore, ESR B, FSHβ B, CTNNAL1 G, miR-27a A allele was favorable for litter size traits. Furthermore, combined genetic effect analysis showed ESR AA FSHβ BB, ESR AA CTNNAL1 CG, ESR AA miR-27a AA, FSHβ BB CTNNAL1 CC, FSHβ BB miR-27a AA and CTNNAL1 CG miR-27a AB was the favorable combined genotype for litter size traits. These results identified favorable alleles and genotypes for litter size traits and suggested a potential selection scheme for litter size in Large White pigs.