Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity. Issue 73 (23rd August 2019)

• Record Type: Journal Article
• Authors: Wang, Jinping; Cheng, Dan; Zhu, Longmin; Wang, Peng; Liu, Hong-Wen; Chen, Mei; Yuan, Lin; Zhang, Xiao-Bing
• Is Part Of: Chemical communications. Volume 55:Issue 73(2019)
• Page Start: 10916
• Page End: 10919
• Publication Date: 2019-08-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04736k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A NIR fluorescent probe based on Si-rhodamine dithiobenzoic acid lactone was used to selectively visualize HOCl during GEN-induced nephrotoxicity for the first time. Abstract : A highly selective lysosome-targeting NIR fluorescent probe (Lyso-SiR-2S ) for HOCl was constructed based on Si-rhodamine B spirodithiolactone. This probe was very effectively employed to sense HOCl produced in various living cells and to visualize fluctuations of endogenous HOCl resulting from GEN-induced acute kidney injury in vivo for the first time.