Photoinduced synthesis of fluorinated dibenz[b, e]azepines via radical triggered cyclization. Issue 73 (16th August 2019)

• Record Type: Journal Article
• Authors: Qi, Xu-Kuan; Zhang, Hong; Pan, Zi-Tong; Liang, Rong-Bin; Zhu, Can-Ming; Li, Jing-Hong; Tong, Qing-Xiao; Gao, Xue-Wang; Wu, Li-Zhu; Zhong, Jian-Ji
• Is Part Of: Chemical communications. Volume 55:Issue 73(2019)
• Page Start: 10848
• Page End: 10851
• Publication Date: 2019-08-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04977k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A simple, mild and efficient approach to access fluorinated dibenz[ b, e ]azepines via visible-light photoredox catalysis is presented. Abstract : A simple, mild and efficient approach to access fluorinated dibenz[ b, e ]azepines via visible-light photoredox catalysis is presented. Inexpensive and commercially available fluoroalkyl anhydrides in concert with pyridine N -oxide are employed as the source of the fluoroalkyl radicals. A one-pot process involving the trifluoroacetylation of unprotected secondary benzyl amines followed by radical cyclization could also afford the desired fluorinated dibenz[ b, e ]azepines.