Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy. Issue 73 (22nd August 2019)

• Record Type: Journal Article
• Authors: Sun, Guangping; He, Zhimei; Hao, Min; Xu, Zuqiang; Hu, Xiao-Yu; Zhu, Jun-Jie; Wang, Leyong
• Is Part Of: Chemical communications. Volume 55:Issue 73(2019)
• Page Start: 10892
• Page End: 10895
• Publication Date: 2019-08-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05859a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bifunctional supramolecular prodrug nanocarriers have been successfully constructed for efficient anticancer drug delivery and tumor diagnosis and therapy. Abstract : Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT ) and a water-soluble pillar[5]arene (WP5 ) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrugDNS-CPT for drug location and cancer therapy.