Effect of solvent polarity in mechanochemistry: preparation of a conglomerate vs. racemate. Issue 73 (22nd August 2019)

• Record Type: Journal Article
• Authors: Sarmah, Kashyap Kumar; Rajbongshi, Trishna; Bhuyan, Achyut; Thakuria, Ranjit
• Is Part Of: Chemical communications. Volume 55:Issue 73(2019)
• Page Start: 10900
• Page End: 10903
• Publication Date: 2019-08-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05687d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The formation of racemic salt vs. conglomerate of isoniazid and tartaric acid was investigated using mechanochemistry. The effect of the polarity and dipole moment of the added liquid used during grinding is discussed. Abstract : Cocrystallization of racemicdl -tartaric acid (dl -ta) and achiral isoniazid (ISN) was investigated using mechanochemistry. Neat grinding (NG) and liquid-assisted grinding (LAG) in the presence of non-polar liquids result in the formation of a conglomerate (ISN·d -ta/ISN·l -ta); whereas LAG with polar liquids yields racemic salt ISN·dl -ta. The effect of solvent polarity and dipole moment in mechanochemistry is discussed.