A unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis. Issue 18 (31st July 2019) - Guo, Xiaowei
Abstract : Chemical investigation of a soil actinomycete strain Streptomyces gamaensis NEAU-Gz11 led to the isolation of three alkaloids1–3 with antiviral activity. Abstract : Chemical investigation of a soil actinomycete strain Streptomyces gamaensis NEAU-Gz11 led to the isolation of three alkaloids1–3 with antiviral activity. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compound1 possesses a new and unique spiro-β-triazinedione-γ-hydantoin skeleton. The racemic feature and the chemical conversion experiments led us to propose a biosynthetic pathway for1 . Compound1 (100 mg L −1 ) showed a strong anti-TMV (tobacco mosaic virus, TMV) activity on the host plants of tomatoes and peppers with inhibition rates of 72.34% and 62.09%, respectively.