SMAD3 gene rs12901499 polymorphism increased the risk of osteoarthritis. Issue 3 (15th May 2018)

• Record Type: Journal Article
• Authors: Yang, Hao-Yu; Hu, Wen-Hao; Jiang, Tao; Zhao, Hui
• Is Part Of: Bioscience reports. Volume 38:Issue 3(2018)
• Publication Date: 2018-05-15
• Subjects: meta-analysis -- osteoarthritis -- rs12901499 polymorphism -- SNP -- SMAD3; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20180380
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : A growing body of evidence suggested that smad family member 3 gene rs12901499 polymorphism was associated with the risk of osteoarthritis. However, the results of previous studies were conflicting. In the present study, we assessed whether smad family member 3 gene rs12901499 polymorphism was associated with the risk of osteoarthritis by the meta-analysis. We searched in the databases of PubMed, Embase, and CNKI. Pooled odds ratios and 95% confidence intervals were calculated. Seven papers involving 11 studies (5344 cases and 9080 controls) analyzed the association between smad family member 3 gene rs12901499 polymorphism and osteoarthritis risk. This meta-analysis confirmed that smad family member 3 gene rs12901499 polymorphism increased the risk of osteoarthritis. Stratification analysis of ethnicity found that rs12901499 polymorphism increased the risk of osteoarthritis among both Asians and Caucasians [G vs A: Asians, OR and 95%CI, 1.34(1.07, 1.69), P =0.012; Caucasians, OR and 95%CI, 1.21(1.13, 1.29), P <0.001]. In addition, subgroup analysis by type of osteoarthritis revealed that smad family member 3 gene rs12901499 polymorphism was correlated with the increased risk of hip osteoarthritis, but not associated with knee osteoarthritis. Sensitivity analysis did not draw different findings. In conclusion, this meta-analysis indicates that smad family member 3 gene rs12901499 polymorphism increased the risk of osteoarthritis.