The role of LRRK2 in cytoskeletal dynamics. (22nd November 2018)

• Record Type: Journal Article
• Authors: Civiero, Laura; Cogo, Susanna; Biosa, Alice; Greggio, Elisa
• Is Part Of: Biochemical Society transactions. Volume 46:Number 6(2018)
• Page Start: 1653
• Page End: 1663
• Publication Date: 2018-11-22
• Subjects: cytoskeleton -- leucine-rich repeat kinase -- Parkinson's disease; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20180469
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well-established roles of LRRK2 in intracellular trafficking pathways and outgrowth of neuronal processes in health and disease conditions.