Association between selenium levels and oesophageal adenocarcinoma risk: evidence from a meta-analysis. Issue 4 (8th July 2016)

• Record Type: Journal Article
• Authors: Hong, Bin; Huang, Lihong; Mao, Ning; Xiong, Tao; Li, Chao; Hu, Liangbo; Du, Ying
• Is Part Of: Bioscience reports. Volume 36:Issue 4(2016)
• Publication Date: 2016-07-08
• Subjects: meta-analysis -- oesophageal adenocarcinoma -- selenium; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20160131
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Quantification of the association between selenium and risk of oesophageal adenocarcinoma (OAC) is still conflicting. The purpose of this meta-analysis is to explore the relationship between selenium levels and OAC risk. PubMed and Web of Knowledge were searched for the related articles. Pooled relative risks (RRs) with 95% confidence intervals (CIs) from random effects models were calculated. Sensitivity analysis and publication bias were conducted. Dose–response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. Five articles involving 748 OAC cases were included in this meta-analysis. Pooled results suggest that higher selenium level was not significantly associated with the risk of OAC (summary RRs=1.08, 95% CIs=0.84–1.39, I 2 =0%). Besides, no significant association was found in case-control studies (summary RRs=1.13, 95% CIs=0.84–1.52, I 2 =0%) or cohort studies (summary RRs=0.99, 95% CIs=0.55–1.78, I 2 =32.6%). A linear dose–response relationship was attested that an increase in dietary selenium intake of 10 μg/day is marginally associated with 1% increase in the risk of developing OAC (summary RRs=1.01, 95% CIs=0.99–1.03), but not statistically significant. No publication bias was found. In conclusion, our analysis indicated that a higher selenium level was not significantly associated with the risk of OAC. The relevant further studies are warranted.