Recent discoveries of influenza A drug target sites to combat virus replication. (9th June 2016)

• Record Type: Journal Article
• Authors: Patel, Hershna; Kukol, Andreas
• Is Part Of: Biochemical Society transactions. Volume 44:Number 3(2016)
• Page Start: 932
• Page End: 936
• Publication Date: 2016-06-09
• Subjects: antiviral discovery -- influenza A -- inhibitors -- resistance -- viral proteins; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20160002
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.