A naphthalimide-indole fused chromophore-based fluorescent probe for the detection of biothiol with red emission and a large Stokes shift. (6th August 2019)

• Record Type: Journal Article
• Authors: Rong, Yifan; Wang, Chen; Chuai, Panfeng; Song, Yunfan; Zhou, Shuang; Hou, Peng; Liu, Xingjiang; Wei, Liuhe; Song, Xiangzhi
• Is Part Of: New journal of chemistry. Volume 43:Number 33(2019)
• Page Start: 13212
• Page End: 13216
• Publication Date: 2019-08-06
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj02709b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : This probe exhibited red emission ( λ max = 590 nm) and a large Stokes shift (143 nm) for the detection of biothiols. Abstract : In this work, a fluorescent probe, 1, using naphthalimide-indole as a fluorophore and a 2, 4-dinitrobenzene sulfonyl group as a recognition site for biothiols (GSH, Cys and Hcy) was developed. The probe can work in aqueous media with a rapid response time (within 4 min). In the detection of biothiols, the probe showed red emission (590 nm), low detection limits (8.97 × 10 −9 M for GSH, 9.87 × 10 −9 M for Cys, and 1.02 × 10 −8 M for Hcy) and a 143 nm Stokes shift. Moreover, this probe exhibited potential practical applications for detecting biothiols in living cells.