The roles of interleukins in perfusion recovery after peripheral arterial disease. Issue 1 (13th February 2018)

• Record Type: Journal Article
• Authors: Chen, Lingdan; Liu, Hanwei; Yuan, Mingjie; Lu, Wenju; Wang, Jian; Wang, Tao
• Is Part Of: Bioscience reports. Volume 38:Issue 1(2018)
• Publication Date: 2018-02-13
• Subjects: Angiogenesis -- Arteriogenesis -- Interleukin -- Peripheral Arterial Disease; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20171455
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the leg makes blood flow dependent on the capacity of neovascularization. There is no current medication that is able to increase neovascularization to the ischemic limb and directly treat the primary problem of PAD. An increasing body of evidence supports the notion that inflammation plays an important role in the vascular remodeling and perfusion recovery after PAD. Interleukins (ILs), a group of proteins produced during inflammation, have been considered to be important for angiogenesis and arteriogenesis after tissue ischemia. This review summarizes the latest clinical and experimental developments of the role of ILs in blood perfusion recovery after PAD.