MicroRNA 486-3P as a stability marker in acute coronary syndrome. Issue 3 (30th June 2016)

• Record Type: Journal Article
• Authors: Wei, Tianling; Folkersen, Lasse; Ehrenborg, Ewa; Gabrielsen, Anders
• Is Part Of: Bioscience reports. Volume 36:Issue 3(2016)
• Publication Date: 2016-06-30
• Subjects: coronary artery disease -- diagnosis biomarker -- microRNA; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20160023
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : A total of 75 cardiovascular patients were investigated for levels of the circulating miR-486-3P . The objective was to find out if any miRNA could distinguish patients with unstable plaque from patients with stable plaque after acute coronary syndrome. Abstract : Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely—particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI ( n =40) with stable-IHD ( n =35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD ( P =0.019).